So my virtualbox windows wouldn’t start after installing Ubuntu 15.10 and ask me to perform the vboxdrv setup after every reboot. The reason is that vboxdrv not starting on boot, with Ubuntu 15.10. This did the trick for me:
sudo /usr/sbin/update-rc.d -f virtualbox remove sudo rm /etc/init.d/virtualbox sudo systemctl enable vboxdrv
This fixes the autostart issue by removing virtualbox remnants and reenabling vboxdrv in systemd.
via: ubuntuforums.org